On your f 150 there is really only a couple of things that can be causing the issue with the drivers door lock to intermittently work and i have seen both of them over a dozen times so you have to have the lock not working to start with and remove the door panel.
Ford f150 driver door lock not working.
2012 f150 wiring harness issue.
This means that the interior lights stay on.
Drivers door not functioning the issue on my 2002 f250 is that my drivers door lock does not lock.
What would be the issue here.
Checked the batteries in the key fobs checked the fuses checked the car battery.
Read that it might be an actuator problem not sure i can fix this.
The automatic door locks do not work.
The 2016 ford f 150 has 9 problems reported for power door locks not working.
Average failure mileage is 5 350 miles.
I have a 2013 f150 the rear passenger door has locked the lock knob is up as if unlocked but door will not open so i am not sure how to even fix it.
Then unplug the lock actuator in the drivers door.
Ford f150 lariat door lock problem.
Is that the most logical thing or is there something else i can try first.
So you could have a problem with the vsm which you said you already ruled out a wiring issue or multiple bad lock actuators unlikely especially if you have a four door model.
I posted a video a.
The vehicle security module vsm operates the door lock actuators in response to input from the door lock switches and key fob.
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In this video we chase down just why the power door locks are not working on this truck with a few tips.
Key fob and manual door locks stopped working.